Vermox

MEBENDAZOLE (Systemic)

Some frequently used brand names are:

In the U.S.—

• Vermox

In Canada—

• Vermox

Generic medicine may be available in the U.S.

Category

• Anthelmintic, systemic

Description

Mebendazole (me-BEN-da-zole) belongs to the family of medicines called anthelmintics (ant-hel-MIN-tiks) . Anthelmintics are medicines used in the treatment of worm infections.

Mebendazole is used to treat:

• Common roundworms (ascariasis);
• Hookworm infections (uncinariasis);
• Pinworms (enterobiasis; oxyuriasis);
• Whipworms (trichuriasis); and
• More than one worm infection at a time.

This medicine may also be used for other worm infections as determined by your doctor.

Mebendazole works by keeping the worm from absorbing sugar (glucose). This gradually causes loss of energy and death of the worm.

Mebendazole is available only with your doctor's prescription (RX medicine), in the dosage form provided below:

• Oral
• Chewable tablets (U.S. and Canada)

Before Using This Medicine

When deciding if it's worth using a medicine, the risk of taking it must be carefully weighed against the benifit it can do. This is the decision you and your doctor are to make together. Concerning mebendazole, the following aspects should be taken into account:

Allergies—Inform your doctor if you have ever experienced any unusual or allergic reaction to mebendazole. Also tell your doctor if you are allergic to any other substances, like foods, preservatives, dyes.

Pregnancy—Mebendazole is not recommended for use during pregnancy. It has been shown to cause birth defects and other problems in rats given a single dose, which was several times the usual human dose. However, mebendazole did not cause birth defects or other problems in women who took this medicine during the first 3 months of pregnancy. Make sure you have consulted on it with your doctor.

Breast-feeding—It is not known if mebendazole passes into the breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. If a mother taking this medicine wish to breast-feed, she should discuss it with her doctor.

Children—This medicine has been tested in a limited number of children 2 years of age or older and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults.

Older adults—There are many medicines that have not been studied specifically in older people. Consequently, it may not be known if they work exactly the same way they do in younger adults or if they cause other side effects or problems in elderly people. There is no specific information comparing use of mebendazole in the elderly with use in other age groups.

Other medicines—Although some medicines should not be used together at all, there are cases when 2 different medicines maybe used together even if an interaction might occur. In such cases, your doctor may advise you to change the dose, or other precautions may be required. Tell your health care professional if you are taking any prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The existence of other medical problems may influence the use of /mebendazole. You should tell your doctor if you have any other medical problems, in particular::

• Crohn's disease or
• Liver disease or
• Ulcerative colitis—Patients with these diseases may have an increased chance of side effects from mebendazole

Proper Use of This Medicine

Mebendazole usually comes with patient directions. Read them carefully before using this medicine.

No special preparations or other steps (for example, special diets, fasting, other medicines, laxatives, or enemas) are necessary before, during, or immediately after taking mebendazole.

Mebendazole tablets may be chewed, swallowed whole, or crushed and mixed with food.

For patients taking mebendazole for hookworms, roundworms, or whipworms :

• To help clear up your infection completely, take this medicine exactly as directed by your doctor for the full time of treatment . In some patients a second course of this medicine may be required to clear up the infection completely. Do not miss any doses .

For patients taking mebendazole for pinworms :

• To help clear up your infection completely, take this medicine exactly as directed by your doctor . A second course of this medicine is usually required to clear up the infection completely.
• Pinworms may be easily passed from one person to another, especially in a household. Therefore, all household members may have to be treated at the same time. This helps to prevent infection or reinfection of other household members. Also, all household members may have to be treated again in 2 to 3 weeks to clear up the infection completely.

For patients taking mebendazole for infections in which high doses are needed:

• Mebendazole is best taken with meals, especially fatty ones (for example, meals that include whole milk or ice cream) . This helps to clear up the infection by helping your body absorb the medicine better. However, if you are on a low-fat diet, check with your doctor .

Dosing—The dose of mebendazole will vary for different patients. Adhere to the orders of your doctor or the instructions on the label . The information below includes only the average doses of mebendazole. If your dose differs, you should not change it unless your doctor tells you to do so.

The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking mebendazole .

• For oral dosage form (chewable tablets):
  • For common roundworms, hookworms, and whipworms:
    • Adults and children 2 years of age and over—100 milligrams (mg) two times a day, morning and evening, for three days. Treatment may need to be repeated in two to three weeks.
    • Children up to 2 years of age—Use and dose must be determined by your doctor.
  • For pinworms:
    • Adults and children 2 years of age and over—100 mg once a day for one day. Treatment may need to be repeated in two to three weeks.
    • Children up to 2 years of age—Use and dose must be determined by your doctor.
  • For more than one worm infection at a time:
    • Adults and children 2 years of age and over—100 mg two times a day, morning and evening, for three days.
    • Children up to 2 years of age—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. You should not double doses.

Storage—To store this medicine properly, follow the instructions below:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is important that your doctor check your progress at regular visits, especially in infections in which high doses are needed. This is to make sure that the infection is cleared up completely and to allow your doctor to check for any unwanted effects.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

For patients taking mebendazole for pinworms :

• In some patients, pinworms may return after treatment with mebendazole. Washing (not shaking) all bedding and nightclothes (pajamas) after treatment may help to prevent this.
• Some doctors may also recommend other measures to help keep your infection from returning. If you have any questions about this, check with your doctor.

For patients taking mebendazole for hookworms or whipworms :

• In hookworm and whipworm infections anemia may occur. Therefore, your doctor may want you to take iron supplements to help clear up the anemia. If so, it is important to take iron every day while you are being treated for hookworms or whipworms; do not miss any doses. Your doctor may also want you to keep taking iron supplements for up to 6 months after you stop taking mebendazole. If you have any questions about this, check with your doctor.

Side Effects of This Medicine

Alongside with its expected effects, any medicine may be the cause of some unwanted effects. Although not all of these side effects may happen, if they do happen they may require medical attention.

Consult your doctor immediately if any of the side effects from the list below occur:

Other side effects that may occur generally do not require any medical attention. These side effects may disappear in the course of treatment as your body gets used to the medicine. Nevertheless, inform your doctor if any of the side effects below persist or became annoying:

Other side effects not mentioned above may also happen in some patients. If you notice any other effects, tell your doctor about it.

Images